Targeting the cell and non-cell autonomous regulation of 47S synthesis by GCN2 in colon cancer.
M. Piecyk, M. Triki, P.-A. Laval, C. Duret, J. Fauvre, L. Cussonneau, C. Machon, J. Guitton, N. Rama, B. Gibert, G. Ichim, F. Catez, F. Bourdelais, S. Durand, J.-J. Diaz, , C. Chaveroux
This study shows GCN2 regulates 47S rRNA synthesis in colon cancer cells under different nutrient conditions, affecting cell survival and response to chemotherapy.
bioRxiv · Feb 8, 2023Cancer Biology