Deciphering the diversity and sequence of extracellular matrix and cellular spatial patterns in lung adenocarcinoma using topological data analysis
I. H. R. Yoon, R. Jenkins, E. Colliver, H. Zhang, D. Novo, D. Moore, Z. Ramsden, A. Rullan, X. Fu, Y. Yuan, H. A. Harrington, C. Swanton, H. M. Byrne, E. Sahai
This study uses topological data analysis to quantify ECM architecture and spatial patterns in lung adenocarcinoma, revealing progressive changes linked to immune exclusion and metabolic shifts.
bioRxiv · Jan 5, 2024 · PreprintCancer Biology