D. Moore

Classification of Variants of Reduced Penetrance in High Penetrance Cancer Susceptibility Genes: Framework for Genetics Clinicians and Clinical Scientists by CanVIG-UK (Cancer Variant Interpretation Group-UK)

The paper develops a framework for classifying variants of reduced penetrance in cancer susceptibility genes to improve variant interpretation consistency.

Single-nucleus and spatial landscape of the sub-ventricular zone in human glioblastoma

The paper builds a single-nucleus RNA-sequencing landscape of the SVZ in GBM patients and identifies therapeutic targets in the T_SVZ microenvironment.

Focused Ultrasound Blood-Brain Barrier Opening Arrests the Growth and Formation of Cerebral Cavernous Malformations

This paper shows that focused ultrasound blood-brain barrier opening can stop and prevent the growth of cerebral cavernous malformations in mice.

Deciphering the diversity and sequence of extracellular matrix and cellular spatial patterns in lung adenocarcinoma using topological data analysis

This study uses topological data analysis to quantify ECM architecture and spatial patterns in lung adenocarcinoma, revealing progressive changes linked to immune exclusion and metabolic shifts.

Vitamin B2 enables peroxisome proliferator-activated receptor α regulation of fasting glucose availability

This study shows that vitamin B2 deficiency impairs PPAR regulation of fasting glucose, and PPAR agonists can rescue this defect.

Evaluation of the broth microdilution methodology for susceptibility testing of Mycobacterium tuberculosis in Peru

The paper evaluates the broth microdilution UKMYC6 plate for susceptibility testing of drug-resistant Mycobacterium tuberculosis strains in Peru, finding good agreement with the agar proportion method for several drugs.

The Role of Colony Temperature in the Entrainment of Circadian Rhythms of Honey Bee Foragers

This study shows that temperature cycles, not just light/dark cycles, can entrain circadian rhythms in honey bee foragers, with individual differences in phase synchronization.

Neonicotinoids Disrupt Circadian Rhythms and Sleep in Honey Bees

This study shows that neonicotinoids disrupt circadian rhythms and sleep in honey bees, likely by stimulating clock neurons, which may impair navigation and social communication.

Development of the first low nanomolar Liver Receptor Homolog-1 agonist through structure-guided design

This study develops the first low nanomolar LRH-1 agonist using structure-guided design, showing increased potency and anti-inflammatory effects in an organoid model.

Quantitative Real-Time Imaging of Glutathione with Sub-Cellular Resolution

This study develops a fluorescent probe to measure glutathione concentrations in the nucleus and cytosol, finding no significant concentration gradient between them.