A tRNA modification balances carbon and nitrogen metabolism by regulating phosphate homeostasis, to couple metabolism to cell cycle progression.
R. Gupta, A. Walvekar, S. Liang, Z. Rashida, P. Shah, S. Laxman
The paper shows tRNA U34-thiolation regulates phosphate homeostasis, linking carbon and nitrogen metabolism to cell cycle progression by controlling metabolic flux and phosphate availability.
bioRxiv · Dec 28, 2018 · PreprintBiochemistry