S. Liang

α-catenin mechanosensitivity as a route to cytokinesis failure through sequestration of LZTS2

This study identifies α-catenin mechanosensitivity as a driver of cytokinesis failure through sequestration of LZTS2, linking it to polyploidization and retinal dystrophy.

Mar1, an HMG-box protein, regulates n-alkane adsorption and cell morphology of the dimorphic yeast Yarrowia lipolytica

This study identifies MAR1, an HMG-box protein, as a regulator of n-alkane adsorption and cell morphology in Yarrowia lipolytica through transcriptional control of relevant genes.

Flight performance, activity and behaviour of breeding pied flycatchers in the wild, revealed with accelerometers and machine learning

This study uses accelerometers and machine learning to analyze flight behavior in pied flycatchers, finding no significant sex differences in flight activity despite males having higher flight performance potential.

Quorum Sensing Positively Regulates CPS-dependent Autographiviridae Phages Infection in Vibrio alginolyticus

This study shows quorum sensing in V. alginolyticus increases CPS-dependent phage infection by upregulating ugd gene expression and CPS synthesis.

Linking root-associated fungal and bacterial functions to root economics

The paper links fungal and bacterial functions in root-associated communities to root economics traits in a subtropical forest.

metaExpertPro: a computational workflow for metaproteomics spectral library construction and data-independent acquisition mass spectrometry data analysis

metaExpertPro constructs metaproteomics spectral libraries and analyzes DIA-MS data, achieving high peptide quantification and low FDR in human fecal samples.

Engraftment and injury repair in regionally conditioned rat lung in vivo by lung progenitors derived from human pluripotent stem cells.

This study demonstrates that human pluripotent stem cell-derived progenitors can engraft in rat lungs and promote injury repair while preventing conditioning-induced damage.

Multi-modal microvascular cerebral blood flow velocity mapping with 14T single-vessel MRI and optical microscopy in the mouse brain

This study combines 14T single-vessel MRI and optical microscopy to map cerebral blood flow velocity in mouse brain microvessels, validating measurements across modalities.

Structural basis for EROS binding to human phagocyte NADPH oxidase NOX2

This study determines the cryo-EM structure of the EROS-NOX2-p22phox complex, revealing how EROS binds to NOX2 and regulates its activation.

DEC1 is an adult clock regulator that links circadian rhythms to functional β-cell maturation

This study shows DEC1 regulates circadian rhythms in β-cells, linking them to metabolic maturation and glucose responsiveness.

The multi-Siglec inhibitor AL009 reprograms suppressive macrophages and activates innate and adaptive tumor immunity

AL009, a multi-Siglec inhibitor, reprograms suppressive macrophages and enhances anti-tumor immunity in preclinical models.

Teacher-student collaborated multiple instance learning for pan-cancer PDL1 expression prediction from histopathology slides

The paper develops MILTS, a teacher-student framework for predicting PDL1 expression from H&E slides using weakly supervised learning, achieving high AUC scores across multiple tumor types.

A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunity

This study shows that a PTP1B/PTPN2 inhibitor enhances T cell anti-tumor immunity in mice, improves tumor response to PD1 therapy, and avoids immune-related toxicities.

CCR9 overexpression promotes T-ALL progression by enhancing cholesterol biosynthesis

This study compares the tumorigenic potential of MOLT4 and JURKAT T-ALL cell lines, finding that CCR9 overexpression enhances cholesterol biosynthesis and promotes T-ALL progression.

Cdc73 protects Notch-induced T-cell leukemia cells from DNA damage and mitochondrial stress

This study identifies Cdc73 as a Notch cofactor that protects T-ALL cells from DNA damage and mitochondrial stress by intersecting with Notch at chromatin to activate oncogenes and repair pathways.

Uptake of tumor-derived microparticles induces metabolic reprogramming of macrophages in the early metastatic lung.

This study shows that uptake of tumor-derived microparticles by macrophages in the early metastatic lung leads to metabolic reprogramming and altered function.

Conformational dynamics and target-dependent myristoyl switch of calcineurin B homologous protein 3

This study investigates the conformational dynamics and target-dependent myristoyl switch of CHP3, revealing that Ca2+ binding and myristoylation independently regulate its function and membrane association.

Toxicity of microplastics and plastic additive co-exposure in liver Disse organoids from healthy donors and patient-derived induced pluripotent stem cells

This study uses hiPSC-derived organoids to show that co-exposure to microplastics and TBBPA increases toxicity in patient-derived organoids compared to healthy ones.

Positive effects of tree diversity on tropical forest restoration in a field-scale experiment

This study shows that planting diverse tree mixtures in logged forests accelerates restoration rates in a large field experiment.

FOXP2 confers oncogenic effects in prostate cancer through activating MET signalling

This study identifies FOXP2 as an oncogene in prostate cancer that activates MET signaling, promoting tumorigenicity through both full-length and truncated forms.

SARS-CoV-2 S protein antagonizes type I interferon downstream signal pathway through interacting and attenuating phosphorylation of STAT1/STAT2

This study identifies how SARS-CoV-2 S protein inhibits type I interferon signaling by interacting with and reducing phosphorylation of STAT1/STAT2, preventing ISGF3 complex formation and ISG expression.

Gene mutations and molecular evolution of the chikungunya virus E1 and E2 from 2014 to 2019

This study analyzes gene mutations in CHIKV E1 and E2 proteins from 2014 to 2019, identifying common mutation sites and their potential impact on immune escape and serological detection.

Staphylococcus aureus nt5 gene contributes to bacterial infection ability to form kidney abscess

This study shows that silencing the nt5 gene in Staphylococcus aureus reduces kidney abscess formation and enhances phagocytosis by host immune cells.

CMTR1 is recruited to transcription start sites and promotes ribosomal protein and histone gene expression in embryonic stem cells

This study shows CMTR1 binds to transcription start sites and promotes expression of histone and ribosomal protein genes in embryonic stem cells, with effects on translation and DNA replication stress.

Construction of a potent pan-vaccine based on the evolutionary tendency of SARS-CoV-2 spike protein.

This study constructs a pan-vaccine (S6) based on the evolutionary patterns of SARS-CoV-2 spike protein to combat diverse variants, showing broader neutralization than existing vaccines.

Increased Brain Volumetric Measurement Precision from Multi-Site 3D T1-weighted 3T Magnetic Resonance Imaging by Correcting Geometric Distortions

This study shows that correcting geometric distortions in multi-site MRI improves volumetric measurement precision in brain scans.

Single-shot rAAV5-based Vaccine Provides Long-term Protective Immunity against SARS-CoV-2 and Its Variants

This study develops a single-dose rAAV5-based vaccine that provides long-term immunity against SARS-CoV-2 and its variants with high neutralizing antibody titers and safety.

Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice

This paper improves prime editors for genome editing in adult mice, enabling pathogenic mutation correction and cancer modeling.

The landscape of transcriptional and translational changes over 22 years of bacterial adaptation

This study examines transcriptional and translational changes in E. coli over 22 years of adaptation, finding that mRNA abundance increases with cell size and that gene expression patterns are similar across replicate populations despite few shared mutations.

Co-infection of influenza A virus enhances SARS-CoV-2 infectivity

This study shows that influenza A virus pre-infection increases SARS-CoV-2 infectivity in multiple cell types and worsens lung damage in mice.