Atrial t-tubules adopt a specialist developmental state while alterations to Ca2+ buffering maintain systolic Ca2+ during postnatal development
C. E. R. Smith, J. D. Clarke, C. J. Quinn, Z. Sultan, H. Najem, N. C. Denham, D. C. Hutchings, G. W. P. Madders, J. L. Caldwell, L. K. Toms, C. Pinali, D. A. Eisner, A. W. Trafford, K. M. Dibb
This study examines atrial t-tubule development in sheep, showing that despite reduced density in newborns, Ca2+ handling is maintained through increased L-type Ca2+ current and sarcoplasmic reticulum content.
bioRxiv · Oct 1, 2023 · PreprintPhysiology