Molecular BiologybioRxivPreprint
5'-triphosphate guanosine RNAs recruit GTP-binding proteins to suppress RIG-I/IFN type I signaling
Jacek Szymański, Magdalena Wołczyk, Ivan Trus…·Gracjan Michlewski
The paper shows that 5'-pppG RNAs are less immunogenic than 5'-pppA RNAs due to interactions with GTP-binding proteins, which may help viruses and Pol III transcripts evade innate immune detection.
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