Molecular BiologyMolecular CellPeer-reviewed
LRRC58 defines an E3 ubiquitin ligase complex sensitive to cysteine abundance
Dylan E. Ramage, Lianne H. E. Wieske, Charlotte Crowe…·Richard T. Timms
The paper identifies LRRC58 as a substrate adaptor in a Cul2 E3 ligase complex that regulates CDO1 degradation in response to cysteine availability, preventing ferroptosis and neurodevelopmental defects.
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