Claudio Zanettini

This study identifies rare germline variants associated with metastatic prostate cancer using an extreme phenotype cohort and validates their functional impact.

This study compares tumor-specific CD8+ T cells from the bone marrow with tumor-infiltrating lymphocytes, finding BM T cells to be more effective in persistence and function for adoptive cell therapy.

The paper develops mechanistic classifiers using biological constraints to improve the robustness and interpretability of gene signatures in cancer prediction.