Christine H. Chung

The paper identifies collagen remodeling as a mechanism that activates a GPCR-mediated immune checkpoint in ADGRG1+ CD8+ T cells, influencing response to immunotherapy.

This study uses computational modeling to explore how spatial interactions between immune cells and collagen fibers influence tumor growth and immune infiltration.

The paper identifies differentially methylated regions in cfDNA from tumor and normal tissues using paired-sample analysis to discover potential biomarkers for head and neck cancers.

This study compares plasma cfDNA methylation profiles pre- and post-surgery in OCSCC patients to identify prognostic and diagnostic biomarkers.

lncDIFF detects differentially expressed long non-coding RNAs with higher power and lower false discovery rate compared to existing methods.

CancerInSilico simulates bulk and single-cell gene expression data from mathematical models to enable benchmarking of time course analysis methods with known ground truth.

The paper uses integrated time course omics analysis to distinguish immediate therapeutic response from acquired resistance in head and neck cancer.