Alka Saxena

The paper introduces a method to create barcoded 3D cell cultures for spatial single-cell analysis using polymer-mediated oligonucleotide delivery and multiplex single-cell RNA sequencing.

The paper introduces a new multiplexed single-cell sequencing method to identify metastable cell states during EMT and shows G-quadruplex DNA stabilization can inhibit EMT.

The paper finds that genetic risk for neuropsychiatric diseases is linked to reduced deep grey matter volume in preterm infants, suggesting a mechanism for how early adversity interacts with genetic vulnerability.

The paper shows that reduced Wnt/β-catenin signaling in microglia of the developing brain causes pro-inflammatory activation and white matter injury, and that restoring this pathway can prevent these effects.

This paper identifies DLG4 (PSD95) expression in microglia and links genetic variation in DLG4 to white matter structure in preterm infants.