Gerben Vader

The SKA complex is a mitotic vulnerability of chromosomally unstable cancers

The paper identifies the SKA complex as a mitotic vulnerability in chromosomally unstable cancers, showing its selective impact on these cells through prolonged mitosis.

Organizational principles governing assembly and activation of the meiosis-specific Red1-Hop1-Mek1 complex

The paper investigates the assembly and activation of the meiosis-specific RHMc complex in budding yeast, showing its role in promoting interhomolog repair and its potential relevance to human cancer.

ESI mutagenesis: A one-step method for introducing point mutations into bacterial artificial chromosome transgenes

The paper introduces ESI mutagenesis, a single-step method for introducing point mutations into BAC transgenes with high precision and efficiency.

Homeostatic control of meiotic G2/prophase checkpoint function by Pch2 and Hop1

The paper reveals that the Pch2-Hop1 module regulates meiotic checkpoint function by both promoting and silencing checkpoint responses depending on cellular context.

A dCas9/CRISPR-based targeting system identifies a central role for Ctf19 in kinetochore-derived suppression of meiotic recombination

The paper uses a dCas9/CRISPR system to target Ctf19c subunits and shows Ctf19 suppresses meiotic crossovers in yeast.

Active transcription and Orc1 drive chromatin association of the AAA+ ATPase Pch2 during meiotic G2/prophase

The paper maps Pch2 localization during meiotic G2/prophase in budding yeast, showing active transcription and Orc1 are required for its chromatin association, while SC components like Zip1 are also involved.