Adèle L. Marston

Sequential pathways preserve kinetochore integrity in meiosis

This study identifies three distinct pathways maintaining kinetochore integrity during meiosis in budding yeast, with distinct temporal requirements and interactions involving Ctf19cCCAN, Mif2CENP-C, and Cse4CENP-A-Okp1CENP-Q-Ame1CENP-U.

Meiotic kinetochore reconstitution identifies chromosome segregation factors

This study reconstitutes vertebrate meiotic kinetochores to identify conserved factors essential for chromosome segregation in mammalian oocytes.

A Kinetochore-Associated Proteasome Pool Drives a Second Pathway of Cohesin Removal during Meiosis

This study identifies a proteasome function that drives centromeric cohesin removal during meiosis II independently of separase activation, revealing a dual role for the proteasome in chromosome segregation.

A conserved mechanism for targeted cohesin loading organises specialised chromosomal domains

This study identifies a conserved mechanism for targeted cohesin loading that organises specialised chromosomal domains in S. pombe.

Interplay between cohesin and TORC1 links chromosome segregation and gene expression to environmental changes

This study shows that TORC1 modulates cohesin functions in chromosome segregation and gene expression, linking environmental changes to chromosome stability.

Multiple pathways couple kinetochore orientation to the meiotic spindle cycle

This study identifies multiple pathways in yeast that coordinate meiosis I chromosome segregation with the meiotic spindle cycle through genetic screening and functional analysis.

Specialisation of meiotic kinetochores revealed through a synthetic spindle assembly checkpoint strategy

The paper introduces a synthetic SAC strategy to study meiosis II in yeast, revealing differences in kinetochore composition and phosphorylation between meiotic metaphase I and II.

Multi-nucleation in two-cell human embryos stems from spindle and metaphase plate incoherence in the first mitosis

The paper investigates the causes of multi-nucleation in two-cell human embryos and finds that spindle and metaphase plate incoherence during the first mitosis leads to this phenomenon.

Attenuation of mosaic aneuploidy and erroneous first mitotic division of human embryos

This study shows that activating KIF2C reduces chromosome segregation errors and aneuploidy in early human embryos, improving IVF outcomes.

A dCas9/CRISPR-based targeting system identifies a central role for Ctf19 in kinetochore-derived suppression of meiotic recombination

The paper uses a dCas9/CRISPR system to target Ctf19c subunits and shows Ctf19 suppresses meiotic crossovers in yeast.