John R. Weir

This study identifies a new closure motif in SYCP2 and shows how HORMAD1 and HORMAD2 form a heterodimer, revising the model of mammalian meiotic axis assembly.

This study shows that G-quadruplexes regulate chromatin accessibility and gene expression in Bloom Syndrome by stabilizing G4s, which enhances chromatin accessibility and promotes gene expression in BLM-deficient cells.

This study characterizes meiotic axis proteins in the brown alga Ectocarpus, revealing novel domain architecture and thermodynamic properties that suggest alternative HORMA domain regulation mechanisms compared to other eukaryotes.

This study identifies RPA as a direct interactor of Mer3/HFM1 helicase, showing its role in enhancing helicase processivity and crossover formation during meiosis.

The paper compares the binding kinetics and structural features of silent and stimulatory flagellin variants with TLR5, identifying structural differences that explain their distinct immune responses.

The paper identifies IHO1-HORMAD1 as essential for seeding the meiotic DSB machinery on chromosome axes, ensuring sufficient DSBs for homologous chromosome pairing in mice.

The paper investigates the assembly and activation of the meiosis-specific RHMc complex in budding yeast, showing its role in promoting interhomolog repair and its potential relevance to human cancer.