Katerina A. Politi

This study shows EED inactivation impairs SCLC tumorigenesis and drives LUAD-to-SCLC transformation, highlighting its role in maintaining SCLC neuroendocrine identity.

This study shows that AURKA inhibition increases DNA replication stress in TP53-mutated cancers, creating a dependency on WEE1 that can be exploited with combined AURKA and WEE1 inhibition to enhance antitumor effects.

The paper identifies METTL7A as a factor that promotes TKI resistance and oncogene amplification in lung cancer by remodeling chromatin structure before copy number gains.

The paper develops OST inhibitors that selectively target STT3A and STT3B, leading to tumor regression in EGFR-mutant lung cancer models.

This study shows CHI3L1 is induced by EGFR activation in NSCLC and promotes EGFR signaling, with anti-CHI3L1 antibodies reversing TKI resistance and inhibiting metastasis.

A genome-wide CRISPR screen with SARS-CoV-2 recovers ACE2 and Cathepsin L and nominates SWI/SNF, TGF-beta signalling and HMGB1 as pro-viral; pathway inhibitors blocked virus-induced death.