BiophysicsbioRxivPreprint
A rigid anchor and a flexible blade: calcium activates gelsolin through an asymmetric conformational ensemble
Bruno Stegani, Loic Girois, Federico Ballabio…·Matteo de Rosa
This study reveals that gelsolin activation involves a graded population shift through an asymmetric conformational ensemble rather than a single structural change.
DOI 10.64898/2026.10.16.759396