Author

Keefe T. Chan

Peter MacCallum Cancer CentreORCID 0000-0001-6114-3724Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Clare L. ScottiD· 2 shared Elaine SanijiD· 2 shared Jiachen Xuan· 2 shared Jian Kang· 2 shared Andrew J. DeansiD· 1 shared Anna S. TrigosiD· 1 shared Carleen Cullinane· 1 shared Daniel Frank· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersMolecular Biology

Clare L. ScottORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintJan 20, 2025

Local nucleolar surveillance mechanisms maintain rDNA stability

Ruofei Liu, Jiachen Xuan, Junqi Pan…·Elaine Sanij

This study identifies localized nucleolar surveillance mechanisms that respond to rDNA damage by activating the nucleolar DNA damage response (nDDR) through R-loop formation and RAD54L protection.

1 citation

humanproteomics

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Cancer BiologybioRxivPreprintApr 29, 2019

Inhibition of RNA Polymerase I Transcription Activates Targeted DNA Damage Response and Enhances the Efficacy of PARP Inhibitors in High-Grade Serous Ovarian Cancer

Elaine Sanij, Katherine M. Hannan, Shunfei Yan…·Richard B Pearson

This study shows CX-5461, an RNA polymerase I inhibitor, enhances PARP inhibitor efficacy in HR-deficient HGSOC by inducing replication stress and DNA damage, overcoming resistance mechanisms.

DOI 10.1101/621623

humanDNA methylation

𝕏 PostBluesky