Sergio Roman‐Roman

This paper introduces PCF-SiM, a framework for quantifying spatial organization in multiplexed imaging data, demonstrating its application in detecting tissue remodeling and spatial interactions in disease models.

The paper shows centrosome amplification in ovarian cancer cells primes them for apoptosis and improves chemotherapy response, independent of multipolar divisions and chromosome instability.

This study identifies NR2F1 as a key regulator of dormancy in uveal melanoma by epigenetically suppressing oncogenic Gαq/11-YAP signaling and cell cycle genes.

The paper uses multi-omics analysis to compare malignant and normal uveal melanocytes, identifying genomic instability and a BAP1 promoter deletion as key features of uveal melanoma.