Kristen D. Felt

This study benchmarks three imaging spatial transcriptomics platforms on FFPE tissues, finding 10x Xenium has higher transcript counts without sacrificing specificity, while all platforms align with RNA-seq data but vary in performance metrics.

The paper provides a pan-cancer spatial analysis of immune biomarkers in the tumor microenvironment using multiplex immunofluorescence data from 2,019 tumors across 14 cancer types.