Hal K. Berman

This study shows that BRCA1 mutations impair the G1/S checkpoint in luminal progenitors, altering their response to irradiation stress compared to basal cells.

The paper profiles proteomic and functional features of mammary epithelial cells in high-risk women, showing how clinical factors influence cellular composition and tumor risk.

Rakaia enables interactive exploration of spatial biology data through a browser-based platform, identifying cell types in non-malignant human breast tissue.

The paper identifies PR-expressing basal cells and PR-primed progenitors, redefining mammary epithelial hierarchy and challenging existing models of breast biology and cancer.

This study identifies FABP7 progenitors as a targetable metabolic root in BRCA1 breast cancer, showing their dysregulation and potential inhibition via fatty acid metabolism disruption.