Molecular BiologyJournal of Molecular BiologyPeer-reviewed
Cancer-Associated Mutations Perturb the Structure and Interactions of the Intrinsically Disordered p53 Transactivation Domain
Lynn Goss Schrag, Xiaorong Liu, Indhujah Thevarajan…·Jianhan Chen
This study shows cancer-associated mutations in p53-TAD disrupt its interactions with regulatory proteins by altering its disordered conformational state rather than directly breaking known interaction interfaces.
24 citations