Huw W. Naylor

This study shows that high mitochondrial DNA heteroplasmy in human organoids with the m.3243A>G mutation causes cortical neuronal disturbances, including axonal degeneration and apoptosis, similar to MELAS patients.

This study develops a framework to monitor and analyze the dynamic formation and dissolution of pseudo-vascular networks in vitro using time-resolved microscopy and image analysis, showing melanoma cells form the most stable networks and respond to specific drug treatments.