Lara Buscemi

Lack of cortistatin drives neuroimmune and vascular dysfunction in brain ischemia

This study shows cortistatin deficiency worsens brain ischemia by increasing neuroinflammation and vascular dysfunction, while cortistatin administration improves outcomes.

Administration of short-chain fatty acids reduces bacterial translocation to peripheral organs and the brain, preserves gut barrier integrity, and mitigates brain injury following stroke.

This study shows that short-chain fatty acids reduce bacterial translocation after stroke, protect gut barrier integrity, and improve neurological outcomes in mice.