Tatsuo Fukagawa

Structural Basis of betaKNL2 Centromeric Targeting Mechanism and Its Role in Plant-Specific Kinetochore Assembly

This study identifies the structural basis of βKNL2 centromeric targeting and its role in plant-specific kinetochore assembly, showing its dependence on the SANTA domain and interactions with centromeric DNA and KNL2.

CCAN forms the spherical shell-like structure in interphase kinetochores

The paper shows that CCAN forms a spherical shell-like structure in interphase kinetochores using in silico and in vivo analyses.

Kinetochore Homeostasis is Maintained by Coordinated Chromatin Stabilization and Soluble Buffering

The paper shows that CENP-T homeostasis is maintained by two distinct pathways involving chromatin stabilization and soluble buffering.

Dual pathways via CENP-C and Mis18C recruit HJURP for CENP-A deposition into vertebrate centromeres

This study identifies two recruitment pathways for HJURP to centromeres via CENP-C and Mis18C, essential for CENP-A deposition and centromere maintenance in chicken cells.

Functional genetics with a hypomorphic CENP-C mutant reveals a regulatory system for chromosome congression

The paper identifies KIF18A as a gene whose knockout causes synthetic lethality with a hypomorphic CENP-C mutant, revealing a regulatory system for chromosome congression.

Molecular details and phospho-regulation of the CENP-T-Mis12 complex interaction during mitosis in DT40 cells

The paper investigates the molecular details and phospho-regulation of the CENP-T-Mis12 complex interaction during mitosis in DT40 cells, showing dual phosphorylation ensures robust interaction and proper mitotic progression.

CENP-C-Mis12 complex establishes a regulatory loop through Aurora B for chromosome segregation

The paper identifies a regulatory loop between CENP-C and Aurora B kinase mediated by the Mis12 complex, essential for correcting kinetochore-microtubule attachment errors during mitosis.