David Potěšil

This study identifies the molecular mechanisms underlying the functional divergence of CK1 paralogs in the Wnt pathway, showing how CK1 and CK1δ/ε have distinct roles and affinities for substrates and complexes.

This study identifies the structural basis of βKNL2 centromeric targeting and its role in plant-specific kinetochore assembly, showing its dependence on the SANTA domain and interactions with centromeric DNA and KNL2.

This study shows eIF4F inhibition increases AMPK activity in BRAF-mutant melanoma cells by both reducing LKB1 and enhancing PP2A activity, suggesting new therapeutic strategies.

The paper identifies SMG7 and eIF4A as a regulatory module that controls P-body condensation and function of meiotic bodies in Arabidopsis.

The paper identifies TRFL7 as a telomere-binding protein in Arabidopsis, showing it functions similarly to human TRF2 in telomere maintenance.

This study identifies SUMOylation sites in KNL2 that are critical for its centromere targeting and interaction with CENH3 in Arabidopsis.

The paper identifies a Wnt-induced phospho-switch in DVL3 that regulates its interaction with Frizzled receptors and Wnt/β-catenin signaling through conformational changes.

This study compares translational regulation in two Arabidopsis accessions during seed germination, identifying differences in mRNA abundance, RNA modifications, and protein expression.

The paper identifies RAI14, EPHA2, and PHACTR4 as essential components of the Wnt/PCP pathway in vertebrates through BioID and zebrafish loss-of-function studies.

The paper identifies TTLL11-mediated polyglutamylation of DVL3 as a novel modification that regulates its phase separation and signaling in the non-canonical Wnt pathway.

This paper develops a bio-inspired scaffold from iPSC-derived cardiac myofibroblasts to model fibrotic ECM effects on cardiomyocytes.

The paper identifies mTORC1 and 7mG-cap dependent translation as regulators of spatial positioning of blastomeres during the 8- to 16-cell transition in mouse embryos.

This study investigates the role of DDX21 in mouse preimplantation embryo development, showing its necessity for cell-fate specification and blastocyst formation through p38-MAPK regulation.

This study shows that p38-MAPK regulates PrE differentiation during mouse blastocyst maturation by controlling translation and rRNA processing through Mybpp1a.