Timothy J. T. Chevassut

This study identifies SPATS2L as a mediator of growth and survival in RUNX1-mutant blast-phase CML through stress granule formation, suggesting it as a therapeutic target.

This study identifies TOE1 as a novel β-catenin interactor in myeloid cells that modulates Wnt signaling via LEF-1 and regulates proliferation through PAK2.

The paper identifies β-catenin-associated mRNAs in myeloid cells through RIP-seq and shows MSI2 interacts with LEF1 mRNA, regulating Wnt signaling and HSPC expansion.

This study identifies CD44 and FAK as therapeutic targets to reverse adhesion-mediated drug resistance in AML by developing an in-vitro BMME model and testing their synergistic effects.