Author

Sean Chia

ORCID 0000-0001-8905-8695Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

Michele VendruscoloiD· 2 shared Alicia González DíaziD· 1 shared Andrea Possenti· 1 shared Benedetta ManniniiD· 1 shared Eleonora Sarracco· 1 shared Gabriel Stephenson· 1 shared Gonçalo J. L. BernardesiD· 1 shared Gustavo Antonio Urrutia· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCell Biology

Michele VendruscoloORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintAug 30, 2024

In situ generation of Aβ42 oligomers via secondary nucleation triggers neurite degeneration and synaptic dysfunction in human iPSC-derived glutamatergic neurons

Alicia González Díaz, Eleonora Sarracco, Andrea Possenti…·Michele Vendruscolo

This study generates Aβ42 oligomers in human iPSC-derived neurons to model Alzheimer's disease and assess inhibitor effects.

2 citations

humanexperimental assay

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BiophysicsbioRxivPreprintAug 9, 2023

Multiplexed Digital Characterisation of Misfolded Protein Oligomers via Solid-State Nanopores

Sarah E. Sandler, Robert I. Horne, Sara Rocchetti…·Michele Vendruscolo

This paper introduces a single-molecule method using solid-state nanopores and DNA barcoding to detect and characterize misfolded protein oligomers, demonstrating its application to α-synuclein in Parkinson's disease.

DOI 10.1101/2023.08.09.552642

proteomicsexperimental assay

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