Author

Benjamin Tuschy

Heidelberg UniversityORCID 0000-0001-9179-3277Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:perturbation response prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Frederik MarméiD· 2 shared Kai DobersteiniD· 2 shared Marc SütterliniD· 2 shared Sebastian BerlitiD· 2 shared Johannes Panther· 1 shared Vivica Messner· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 14 mutual co-author links

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2 shared papersCancer Biology

Frederik MarméORCID

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2 papers

Recent·Most cited

Cancer BiologyHeliyonPeer-reviewedFeb 18, 2026

Inhibition of Replication Origins and ATR Synergistically Activates the Innate Immune System in Cancer Cells

Kai Doberstein, Johannes Panther, Sebastian Berlit…·Frederik Marmé

The paper shows that inhibiting replication origins and ATR together increases genomic instability and innate immune activation in ovarian cancer cells, but not in normal cells.

1 citation

humanbulk RNA-seq

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Cancer BiologybioRxivPreprintMar 27, 2025

Interplay between BET Proteins and the Pre-Replication Complex Unveils Therapeutic Vulnerabilities in Cancer

Kai Doberstein, Vivica Messner, Sebastian Berlit…·Frederik Marmé

The paper investigates the interaction between BET proteins and the pre-replication complex in cancer cells, showing that combining BET and CDC7 inhibitors enhances therapeutic effects through DNA damage and genomic instability.

DOI 10.1101/2025.03.27.645172

humanexperimental assay

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