Jian H. Song

This study shows that activating RET mutations in medullary thyroid cancer (MTC) cells promote osteoblastic bone metastases by increasing osteoprotegerin (OPG), which inhibits bone resorption and is linked to poor patient survival.

This study identifies a prostate cancer-induced endothelial-to-osteoblast transition that creates an immunosuppressive bone tumor microenvironment, reducing the effectiveness of immune checkpoint therapy in bone metastatic castrate-resistant prostate cancer.