GenomicsAntimicrobial Agents and ChemotherapyPeer-reviewed
The role of epistasis in amikacin, kanamycin, bedaquiline, and clofazimine resistance in Mycobacterium tuberculosis complex
Roger Vargas, Luca Freschi, Andrea Spitaleri…·Maha Reda Farhat
The paper demonstrates epistatic interactions in Mycobacterium tuberculosis complex that can reverse antibiotic resistance, specifically showing that eis promoter mutations cannot confer resistance if paired with LoF mutations in the eis coding region.
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