Giuseppe Andrea Sautto

This study designs influenza A(H3N2) vaccine candidates using protein language models and machine learning, showing two candidates provide broad protection against current and drifted strains in mice.

This paper introduces a high-throughput method to assess the affinity distribution of antigen-specific B cells using an adapted ImmunoSpot assay, demonstrating its application in detecting affinity maturation after vaccination.

This study shows that delayed innate immune responses to influenza B virus in ferrets lead to weaker antibody responses compared to influenza A virus.

This paper introduces MAGE, a model that generates paired human antibody sequences against specific targets, validated against SARS-CoV-2, H5N1, and RSV-A.

The paper identifies a pan-betacoronavirus antibody that binds the S2 subunit of spike proteins and induces Fc-dependent antiviral responses, offering insights into non-neutralizing antibody protection.