This study uses long-read sequencing to analyze VSG diversity in T. brucei infections, revealing higher expressed diversity and early mosaic gene formation than previously observed.

31 citations

mouselong-read sequencing

𝕏 PostBluesky

GeneticsPLoS neglected tropical diseasesPeer-reviewedFeb 22, 2018

No evidence for association with APOL1 kidney disease risk alleles and Human African Trypanosomiasis in two Ugandan populations

Magambo Phillip Kimuda, Harry A. Noyes, Julius Mulindwa…·Enock Matovu

The paper investigates associations between APOL1 variants and HAT risk in Ugandan populations, finding no significant associations after correction for multiple testing.

19 citations

humanstatistical model

𝕏 PostBluesky

GeneticsPLoS neglected tropical diseasesPeer-reviewedOct 23, 2017

Candidate genes-based investigation of susceptibility to Human African Trypanosomiasis in Côte d’Ivoire

Bernardin Ahouty, Mathurin Koffi, Hamidou Ilboudo…·Assanvo Simon-Pierre N’Guetta

This paper investigates genetic associations with susceptibility to Human African Trypanosomiasis in Côte d’Ivoire using a candidate gene approach and finds suggestive but non-significant associations in several immune-related genes.

18 citations

humanGWAS summary statistics

𝕏 PostBluesky

GenomicsbioRxivPreprintOct 12, 2017

Evidence of population specific selection inferred from 289 genome sequences of Nilo-Saharan and Niger-Congo linguistic groups in Africa

Julius Mulindwa, Harry A. Noyes, Hamidou Ilboudo…·Enock Matovu

The paper analyzes 289 genome sequences from Nilo-Saharan and Niger-Congo populations to identify population-specific selection signatures linked to disease resistance.

2 citations

humanwhole-genome sequencing

𝕏 PostBluesky