Cell BiologybioRxivPreprint
Preconditioning of human iPSCs with doxorubicin causes genome-wide transcriptional reprogramming in iPSC-derived cardiomyocytes linked to mitochondrial dysfunction and impaired cardiac regeneration
Michelle Westerhoff, Nahal Brocke‐Ahmadinejad, Yulia Schaumkessel…·Andreas S. Reichert
This study shows that low-dose doxorubicin treatment of human iPSCs causes mitochondrial dysfunction and transcriptional changes that impair cardiac regeneration in derived cardiomyocytes.
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