Author

James A. DeCaprio

Brigham and Women's HospitalORCID 0000-0002-0896-167XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

Chen Chen· 1 shared Denise J. RoeiD· 1 shared Fatmata F. SesayiD· 1 shared Gillian D. Paine-Murrieta· 1 shared Hunain KhawajaiD· 1 shared James T. Lim· 1 shared Jiawen YangiD· 1 shared Konstantin RiegeiD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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1 shared paperCancer Biology

Chen Chen

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Cancer BiologyJournal of Clinical InvestigationPeer-reviewedFeb 11, 2025

Integrative analysis reveals therapeutic potential of pyrvinium pamoate in Merkel cell carcinoma

Jiawen Yang, James T. Lim, Paul Victor Santiago Raj…·Megha Padi

This study identifies pyrvinium pamoate as a potential therapy for Merkel cell carcinoma by targeting Wnt signaling and multiple cancer vulnerabilities.

8 citations

humanbulk RNA-seq

𝕏 PostBluesky

BioinformaticsNAR CancerPeer-reviewedJan 13, 2022

TargetGeneReg 2.0: a comprehensive web-atlas for p53, p63, and cell cycle-dependent gene regulation

Martin Fischer, Robert J. Schwarz, Konstantin Riege…·Steve Hoffmann

TargetGeneReg 2.0 expands its database to include non-coding genes and new transcription factors, enabling analysis of gene regulation by p53, ΔNp63, and cell cycle signaling.

50 citationstop 3%

humanbulk RNA-seq

𝕏 PostBluesky

Molecular BiologyCell CyclePeer-reviewedFeb 17, 2019

DYRK1A regulates the recruitment of 53BP1 to the sites of DNA damage in part through interaction with RNF169

Vijay Menon, Varsha Ananthapadmanabhan, Selene K. Swanson…·Larisa Litovchick

This paper identifies DYRK1A's role in DNA repair by regulating RNF169-mediated 53BP1 recruitment to DSB sites, with implications for DNA damage therapy response.

56 citations

humanmouse

𝕏 PostBluesky