Carlo Pappone

This study uses hiPSC-derived cardiomyocytes to show that cardiotoxic light chains reduce electrophysiological function, while non-toxic light chains have no effect.

This paper introduces a label-free, real-time single-molecule immunoassay using iSCAT to directly observe protein-protein interactions with high sensitivity and molecular-weight resolution.

This study identifies nanobodies that counteract the toxicity of an amyloidogenic light chain by stabilizing a partially open dimeric conformation, revealing insights into toxicity mechanisms.