Genetic & Genomic MedicinemedRxivPreprint
Genetic regulation of TERT splicing contributes to reduced or elevated cancer risk by altering cellular longevity and replicative potential
Oscar Flórez-Vargas, Michelle Ho, Maxwell H. Hogshead…·Ludmila Prokunina‐Olsson
This study identifies VNTR6-1 and rs10069690 as regulators of TERT splicing and expression, influencing cancer risk and telomere dynamics through altered telomerase isoform ratios.
DOI 10.1101/2024.11.04.24316722