Cancer BiologybioRxivPreprint
XPC loss-of-function triggers melanomagenesis through CDKN2A downregulation
Vipin Shankar Chelakkot, Kiara Thomas, Todd Romigh…·Joshua Arbesman
This study identifies an XPC variant that promotes melanomagenesis by downregulating CDKN2A through promoter binding, independent of its nucleotide excision repair function.
DOI 10.1101/2025.04.03.646637