Author

Andrew D. Mitchell

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research InstituteORCID 0000-0002-2018-4359Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Hanfeng LiniD· 1 shared Jennifer Ann WoyachiD· 1 shared Jin WangiD· 1 shared Qi XL· 1 shared Ran ChengiD· 1 shared Shrilekha MisraiD· 1 shared Xin Yu· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

Hanfeng LinORCID

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1 paper

Recent·Most cited

BiochemistrybioRxivPreprintFeb 15, 2026

Sub-stoichiometric Degradation is Dispensable for Potent PROTACs: A Case Study for Irreversible Covalent BTK Degraders

Ran Cheng, Hanfeng Lin, Xin Yu…·Jin Wang

This paper develops and characterizes PSIRC3, a covalent PROTAC for BTK, showing it achieves potent degradation with sub-nanomolar potency and high selectivity, challenging the necessity of catalytic turnover for PROTAC efficacy.

1 citation

humanexperimental assay

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