Ludger Johannes

This paper shows that EndoA3-mediated CIE and retrograde transport in cancer cells affect immune synapse organization and CD8 T cell responses by redistributing ICAM1 and ALCAM.

This study identifies GL-Lect driven endocytosis as a driver of metastatic plasticity in breast cancer and shows pharmacologic inhibition can suppress invasive phenotypes.

This study identifies Galectin-3 as a novel ligand for GPRC5A, demonstrating its role in mediating endocytosis of the orphan GPCR in colorectal cancer cells.

The paper identifies two TRM subpopulations in NSCLC patients and shows that only DP TRM predicts response to PD-1 blockade immunotherapy.

This study identifies STAM interaction with Hrs as critical for IFN-α-induced JAK/STAT activation at the early endosome, revealing endosomal sorting's role in differential signaling.

This study shows that Cav3 mutations in human dystrophic myotubes impair caveolae function, leading to defective mechanoprotection and aberrant IL6/STAT3 signaling.