Andrew John Lees

The paper shows that white matter macrostructure loss and elevated plasma neurofilament light chain levels are associated with poor outcomes in Parkinson's disease.

The paper examines dynamic brain state transitions in Parkinson's disease patients with visual hallucinations, finding altered temporal dynamics and links to neurotransmitter systems.

The paper shows that visual dysfunction in Parkinson's disease is linked to cognitive decline and white matter damage over time.

The paper investigates environmental and genetic risk factors for Parkinson's disease using UK Biobank data, showing gene-environment interactions and improved prediction with polygenic risk scores.

The paper identifies common LRRK2 locus variation associated with survival in progressive supranuclear palsy, linking it to gene expression regulation and suggesting therapeutic implications for tauopathies.

The paper introduces a new parameter, VS, to detect bradykinesia in Parkinson's disease patients using the BRAIN tap test and validates its reliability across different hardware platforms.

The paper evaluates abbreviated versions of the UPSIT smell test to detect hyposmia, finding that a 4-item test outperforms existing shorter versions in sensitivity and specificity.

This study estimates the heritability of dementia with Lewy bodies (DLB) and finds it to be higher than previous estimates, with low variance explained by polygenic risk scores from Parkinson's or Alzheimer's disease.

This study identifies a genetic variant at the TRIM11 locus associated with Progressive Supranuclear Palsy phenotype through GWAS and validates it in independent cohorts.