Josef Šivic

This study uses ultrahigh-throughput screening to identify mutations in dehalogenases that modulate substrate access and binding, revealing distal functional effects on enzyme dynamics.

This study shows taurine inhibits ApoE4 aggregation and reduces its pathophysiological effects, similar to tramiprosate and 3-sulfopropanoic acid.

MARTS-DB is a manually curated database of terpene synthase mechanisms and reactions, providing over 2,600 reactions and supporting computational analysis and machine learning.

An all-atom diffusion model unifying biomolecular structure prediction and sequence-structure generation designs experimentally validated nanobodies, mini-proteins, and linear or cyclic peptides across 26 diverse targets.

The paper introduces EnzymeExplorer, a machine-learning pipeline that predicts enzyme function, discovering new terpenoid synthases in archaea and expanding their known taxonomic distribution.