Christopher T. Ritchlin

SPP1hi macrophages in RA synovial fibrin deposits promote tissue hyperplasia.

This paper introduces a deep learning model for automated joint space detection in micro-CT images of mouse paws, significantly improving segmentation accuracy compared to semi-automated methods.

This study identifies Efhd1+ telocytes in the synovial lymphatic system and shows their role in lymphatic drainage and protection against inflammatory-erosive arthritis.

This study identifies granzyme K as a driver of a novel complement activation pathway independent of classical, lectin, or alternative pathways.

The paper develops SCENT, a method to create cell-type-specific enhancer-gene maps from single-cell multimodal data, identifying causal variants and genes for diseases.

The paper maps cell-type-specific eQTLs for HLA genes across multiple tissues and identifies dynamic regulation of HLA-DQ genes in immune cells.

The paper deconstructs RA synovium using single-cell data to identify six cell type abundance phenotypes associated with distinct inflammatory states.