Marlene Sophia Kohlhepp

Hepatocyte-, but not myeloid cell-Rictor/mTORC2 deficiency moderately attenuates steatotic liver disease induced by intake of a choline-deficient, amino acid-defined high-fat diet

This study shows that hepatocyte-specific mTORC2 deficiency slightly reduces liver disease from a choline-deficient diet, while myeloid cell deficiency has no effect.

Neonatal liver niches program T cell tolerance

The paper identifies a neonatal liver program that expands regulatory T cells while limiting conventional T cell activation, influencing susceptibility to viral infections and protection against liver disease.