Molecular BiologybioRxivPreprint
Omecamtiv mecarbil and Mavacamten target the same myosin pocket despite antagonistic effects in heart contraction
Daniel Auguin, Julien Robert‐Paganin, S. Réty…·Anne Houdusse
This study shows Omecamtiv mecarbil and Mavacamten target the same myosin pocket but have antagonistic effects on heart contraction through structural and simulation analyses.
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