Cancer BiologybioRxivPreprint
Therapy-associated mutagenesis at CTCF binding sites is shaped by chromatin context and DNA repair capacity
Kevin C.L. Cheng, Zoe P. Klein, Jigyansa Mishra…·Jüri Reimand
The paper examines therapy-associated mutagenesis at CTCF binding sites across 4,870 tumor genomes, finding increased mutation enrichment at these sites under radiotherapy and trifluridine treatment.