Author
Koch Institute for Integrative Cancer Research At MITORCID 0000-0002-4405-8357Unclaimed ORCID profile · follow to get notified of new preprints
Mutual co-authors in cluster
4 papers
Recent·Most cited
Dig Bijay Mahat, Heena Kumra, Sarah A Castro…·Phillip A. Sharp
This study shows mutant p53R172H in pancreatic cancer enhances immunosuppressive chemokine Cxcl1 expression via enhancer activation, reducing immune checkpoint inhibitor efficacy.
Rei Kudo, Anton Mikhailovich Safonov, Catherine Jones…·Sarat Chandarlapaty
The paper identifies TP53 loss and MDM2 amplification as factors associated with poor long-term response to CDK4/6 inhibition in breast cancer and shows that CDK2 inhibition can overcome this resistance.
Anton Mikhailovich Safonov, Antonio Marra, Chaitanya Bandlamudi…·Pedram Razavi
The paper identifies how germline and somatic mutations interact to cause resistance to CDK4/6 inhibitors in breast cancer and proposes a sequential treatment strategy using PARP inhibitors.
Hojun Li, Jideofor Ezike, Anton Afanassiev…·R. Grant Rowe
The paper uses single cell RNA-seq to study human hematopoietic stem and progenitor cells (HSPCs) across development and aging, revealing age-related transcriptional changes and differentiation trajectories.