GeneticsThe Journal of Cell BiologyPeer-reviewed
Reduction of insulin/IGF-1 receptor rejuvenates immunity via positive feedback circuit
Yujin Lee, Yoonji Jung, Dae‐Eun Jeong…·Seung‐Jae Lee
This study shows that reducing insulin/IGF-1 receptor activity delays immunosenescence and rejuvenates immunity in C. elegans through a positive feedback circuit involving DAF-16/FOXO and HSF-1.
40 citations