Hyperactive STAT1 Promotes T Follicular Helper Type 1 Cell Differentiation to Trigger Autoimmunity
Ran Chen, Xuemei Chen, Jigui Yang…·Yanjun Jia
Overactivated STAT1 promotes Tfh1 differentiation to drive autoimmunity.
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Hiroshima UniversityORCID 0000-0002-4622-5657Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
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Ran Chen, Xuemei Chen, Jigui Yang…·Yanjun Jia
Overactivated STAT1 promotes Tfh1 differentiation to drive autoimmunity.
Çiğdem Sevim Bayrak, Aayushee Jain, David F. Stein…·Yuval Itan
The paper identifies gene- and protein-level features distinguishing gain-of-function and loss-of-function mutations using NLP and machine learning on a new database of pathogenic mutations.
David B. Beck, Mohammed Abul Basar, Anthony J. Asmar…·Achim A Werner
This study identifies OTUD5 as essential for chromatin remodeling during development, showing its role in preventing degradation of chromatin regulators and maintaining proper gene expression networks.