BiochemistryCommunications BiologyPeer-reviewed
Artemisinin-resistant Plasmodium falciparum Kelch13 mutant proteins display reduced heme-binding affinity and decreased artemisinin activation
Abdur Rahman, Sabahat Tamseel, Romain Coppée…·Souvik Bhattacharjee
This study shows that PfKelch13 mutants have reduced heme-binding affinity, leading to decreased artemisinin activation and contributing to artemisinin resistance.
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