GenomicsbioRxivPreprint
Programmable eukaryotic protein expression with RNA sensors
Kaiyi Jiang, Jeremy G. Koob, Xi Dawn Chen…·Jonathan S. Gootenberg
This paper introduces RADARS, a programmable RNA-sensing technology that uses ADAR-mediated RNA editing to control protein expression based on target RNA transcripts in mammalian cells, with applications in gene therapy and synthetic biology.